This method outperforms similar existing methods both in the accuracy of prediction and in the coverage of domain interaction space.
The comprehensive, non-redundant dataset of PPIs compiled by us in this work contains 209,165 PPIs that has an extensive coverage of domain space (two-third of the entire domain/family space in InterPro).
Their work extended the coverage of domain annotation effectively and provided solid foundation for predicting protein function.
Importantly, both coverage and domain size of LOCKs increase upon differentiation of mouse embryonic stem cells (ESCs) [ 11].
Information like molecular weight, % sequence coverage, and domain information of some putative functional significant proteins is depicted in Table 3.
Some known salivary proteins and novel proteins and their details like molecular weight, peptides number, calculated pI, sequence coverage, and domain information are depicted in tables (Tables 1 and 2).
To look at the coverage of domains in fungal sequences in a different way, the number of domains per sequence is presented in Figure 3 and Figure 4, averaged over the 30 original and five new fungal genomes, respectively.
Nevertheless, evolutionary-based databases have higher coverage of domains than structure-based databases [ 14, 25].
Our results show that FPfam provides improved sensitivity and coverage for domains represented in the library.
