Although this study explored a relatively large number of twin pairs, the findings have not yet been replicated and were based on a relatively low-coverage array (Illumina 27 K) that examines only 0.7% of variable CpG sites [ 88].
For a full coverage resolution array, approximately 30,000 BACs have been arrayed [ 24], increasing the resolution with another order of magnitude.
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By using full coverage BAC array CGH, Wilson et al. discovered that human DNA copy-number is often increased relative to chimpanzee and gorilla.
Tiling, whole genome coverage BAC arrays (38,043 BAC clones) were produced at the SCIBLU Genomics Center, Department of Oncology, Lund University, Sweden http://www.lth.se/sciblu as previously described [ 20].
To improve genome coverage, the arrayed P. berghei genomic DNA library in the pJAZZ-OK linear plasmid (Lucigen) that provides the starting point for vector production was doubled in size to ∼10,000 clones.
Nowadays, SNP arrays have been routinely used for CNV detection in human and other organisms [ 2, 8, 10, 25], and manufacturers of SNP genotyping arrays have incorporated non-polymorphic markers into their SNP genotyping arrays to improve the coverage of SNP arrays for CNV analyses [ 26].
More recently, Winzeler et al. [14] determined a subset of DNA sequence variation among a set of 14 S. cerevisiae strains using low-coverage oligonucleotide arrays and discovered 11,115 sites of variation among them.
