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Four chemotherapy courses concurrent with radiotherapy (courses 5 to 8) were administered days 43, 50, 64 and 71 with the ninth week used as a rest week.
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This approach is more easily and safely obtained by dose-escalating long-course concurrent chemoradiotherapy.
Two phase III trials have directly compared short-course preoperative radiotherapy followed by immediate surgery versus long-course concurrent chemoradiotherapy followed by a delay in surgery.
Of course, concurrent administration of vaccines is desirable only when immunogenicity is not adversely effected, and safety is similar or improved.
Eligible patients received weekly intravenous docetaxel 20 mg/m2 for 6 courses with concurrent radiotherapy.
The cell line model data presented here suggest that even short courses of concurrent administration can cause marked cytotoxicity and/or apoptosis.
One year prior, he was diagnosed with stage T3N1M0 nasopharyngeal carcinoma (NPC) according to the Union for International Cancer Control UICCC, 2009) classification and treated with radical radiotherapy (70 Gy in 35 fractions, 5 fractions per week) combined with 3 courses of concurrent cisplatin chemotherapy.
During the initial period of this trial (before June 1999), two courses of concurrent chemotherapy comprising 96-h continuous infusion of cisplatin 15 mg m−2 day−1 +5-FU 300 mg m−2 day−1 were planned at the first and fifth weeks of radiotherapy.
A time course of concurrent cerebrospinal fluid (CSF) and plasma samples were taken following administration.
Subthreshold GAD was also seen to worsen the course of concurrent somatic diseases [ 50].
All 41 patients completed a total dose of 60 Gy radiotherapy immediately after HBO with one course of concurrent chemotherapy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com