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Some have problems at all stages, others have sporadic difficulties, and a proportion fail to graduate at all, either leaving voluntarily or having their course terminated.
Of those who left, two left within the first few weeks, one took suspension in year 1 but did not return, four left voluntarily after their 2nd year (i.e. at the end of the pre-clinical phase), and five had their course terminated after academic failure.
Primary efficacy end points, against placebo, were the number of courses (a course terminated whenever an attack occurred or after 1 month) with and without attacks (two studies), the number of attacks per month (two studies), the average flare intensity (one study), the daily score of disease activity (one study) and the number of attacks normalised for the number of days (one study).
Based on the calculated volume, before the treatment commenced on day 1, we measured also the unaffected limb to obtain the degree of edema severity, ES, and after the course terminated on day 5, we assessed the rate of volume reduction, VR, as depicted.
Some students who were identified, for example, via APC attendance, had actually suffered only a minor or one-off drop in performance, and were subsequently eliminated from the database ○ left the course voluntarily ○ course terminated Further variables were generated as required during the analysis, to create 'flags', and these are described in the Results section.
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Fourteen students failed to progress beyond Year 2, nine withdrawing and five having their courses terminated.
Of the remaining 73, 61 left the course voluntarily and 12 had their courses terminated in Year 1 or 2 for academic failure.
We performed separate analyses of the retention of therapeutic safety in which treatment courses terminated for any other reason than adverse events were additionally censored.
The highest rates of attrition (46/1188, 4%) occurred during the first two years (largely preclinical studies), with 34 students leaving voluntarily, including 11 within the first semester, and 12 having their courses terminated for academic failure.
In the remaining cases, the pregnancy course was terminated and the defect was confirmed in elected autopsies.
When the original course was terminated for inefficacy within the first 12 months of treatment (n = 22), inefficacy recurred in 59.1% (n = 13) of the re-employed course.
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