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With imaging and pretargeted therapeutic strategies, the time course of uptake is critical in determining when to take an image or deliver a secondary reagent.
AIMS: The extent to which hospital and geographic characteristics influence the time course of uptake of evidence from key clinical trials and practice guidelines is unknown.
In addition, image acquisition and especially image analysis will need to take advantage of information arising from the time course of uptake to create more robust and molecularly accurate measures of regional biology [23].
METHODS AND RESULTS: Using chronological data from the GRACE registry (n=12666, July 1999 to December 2001), we test the hypothesis that hospital and geographic characteristics influence the time course of uptake of evidence-based guideline recommendations for acute coronary syndromes (ACS) with and without ST elevation.
This time course of uptake is slightly faster then what we have previously reported [ 34].
In conclusion, various chemotherapeutic agents, commonly used in the treatment of breast cancer, have different effects on the time course of uptake of both FDG and FLT in vitro.
Similar(53)
The model took advantage of known physiological constraints in estimating the time-course of uptake, namely that 64Cu should be delivered from the blood.
We studied the time-course of uptake of NBD-PC-coated SWCNT, NBD-PS-coated-SWCNT and NBD-PS-coated and Annexin V treated SWCNT by RAW264.7 macrophages.
To further study the relationship between NST-732 uptake by the apoptotic cells and caspase activation, we compared the time-course of uptake of NST-732 into Jurkat cells from initiation of exposure to the apoptotic trigger anti-Fas-Ab, with the respective time-course of uptake of the fluorogenic caspase substrate FAM-VAD-FMK.
In addition to these general considerations regarding the rim uptake, the time course of FET uptake in relation to the RIT cycles also has to be taken into account.
For further studies it would be extremely interesting to assess the question of clinical relevance of tracer uptake thresholds, to correlate component position with tracer uptake and to elucidate the natural course of tracer uptake before and after TKA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com