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Several significant advances are achieved in the course of the model development.
To overcome limitations caused by parameter uncertainties the most sensitive model parameters are simultaneously estimated in the course of the model selection framework.
In the first alternative scenario, the exponential function was used to predict patient response status beyond 4 weeks (i.e. beyond the randomised phase) assuming a constant monthly rate (~31 %) of response loss throughout the course of the model.
During the whole time course of the model, PXN is a potential target of several downregulated (mmu-miR-203, -218, -30b, -30c, -27a and -21) and upregulated (mmu-miR-20b, -466g, -30d and -145) miRNAs.
That is, by simply varying the frequency of rainfall to which the ideal oviposition cycle resonates, Cx. nigripalpus birth and death rates approximately match over the course of the model simulation.
In the course of the model reduction, a FL can be reduced at most to its minimal form, an autoregulation.
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We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis.
In the course of describing the model we have pointed to various sources of evidence that support the inside-out model.
Loesser's songs are wonderful, of course, top-of-the-line models of tuneful wit and economy.
In the course of reconstructing the model, several assumptions about the presence or absence of reactions had to be made.
Time course of the animal model is shown in the Figure 1. Figure 1 Time course of the animal model.
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