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It is also clear that this variation occurs in the course of pathway loss (indicated by unfilled circles in Figure 6), rather than acquisition, consistent with our observations for 5-gene pathways.
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A schematic illustration of the course of the pathway is depicted in Figure 1.
A schematic illustration of the course of the pathway is depicted in Figure 2.
In other words, the factors' weight is variable in the definition of course of each pathway.
In most cases, over 90% of the cells retrogradely labeled following injections of horseradish peroxidase along the course of this pathway were located in the intermediate grey lamina.
This is significant because it emphasizes that the subtle difference in signaling due to promoter polymorphisms can alter the course of biochemical pathway resulting in variation in disease phenotype.
During the course of this pathway proteins are linked to a chain of ubiquitin molecules under regulation of E3-ligases such as MuRF-1 and MAFBx and, subsequently, recognized and degraded by the proteasome.
During the course of the pathway the management moves from the patient level to a 'mouth level' analysis of risk factors such as plaque control to 'tooth level' risk factor management such as tooth anatomy and finally to 'site level' risk factor management such as bleeding on probing.
In addition, the Pgm reaction links the maltose and maltodextrin utilization pathways to the glycolysis, as in the course of these pathways also glc-1-P is formed [ 13, 23, 24].
Overlapping and non-overlapping pathways and networks demonstrate the sequential changes in the course of molecular pathways in the hippocampus of ischemic mice.
An alternative to defining white-matter ROIs or using voxelwise TBSS analysis to examine the whole brain white matter is to use diffusion tractography to estimate the course of fiber pathways through the white matter and then derive measures such as FA from within those pathways.
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CEO of Professional Science Editing for Scientists @ prosciediting.com