Sentence examples for course of pathology from inspiring English sources

These data indicate that midline slits given within 1 24 h postinjury had significantly (p  =  0.007) altered the course of pathology at the lesion site, in that the damaged area at the lesion epicenter was reduced from 35.3% in the control group to 24.2% or 25.8% in the groups with myelotomy at 1 h or 24 h, respectively (Fig. 2).

Previous investigators have shown tremendous differences in the course of pathology between different muscle groups in mdx mice, with extraocular muscle suffering no pathology, triceps brachii exhibiting more pathology than other limb muscles and diaphragm muscle experiencing the most severe pathology [58], [59].

Furthermore, in APPSL/PS1M146L transgenic mice, in which the time course of pathology is closer to that seen in most currently available models, Cer did not accumulate in disease-associated brain regions (cortex and hippocampus) [ 136].

As mentioned above, SLE can present with a variable course of pathology, and affected individuals frequently go into remission and experience sudden flares with unknown cause (Petri et al., 1991).

We have also revealed an early and selective up-regulation of cell death pathways, and it will now be key to understand how cell death pathway activation relates to the time course of pathology within the motor unit.

Based on these preoperative diagnostic findings, we could not exclude a risk of thrombus formation and caseous necrosis occurring during the course of this pathology.

The osteotomy performed did not change the course of the pathology and the postoperative rehabilitation therapies probably even worsened the final outcome.

The clinical course of this pathology shows a poor response to different therapies including steroids and other immuno-suppressors, and often evolves to irreversible respiratory failure [4].

These combined observations raise the possibility that DYRK1A may be a critical contributor to tau dysfunction and tau pathology of Alzheimer's disease and, moreover, that this kinase may be an important therapeutic target for pharmacological interventions seeking to modify the course of tau pathology in AD.

Two studies showed that a loss of mutant SOD1 expression in muscle did not change disease outcome in mutant SOD1 mice [29], [30], suggesting that either minute quantities of remaining mSOD1 in muscle are still sufficient to trigger the disease or that the knockdown of mutant SOD1 in muscle was performed too late in the course of the pathology.

In this study, we extend previous published findings from our lab and others that show DYRK1A is involved in phosphorylation of tau protein on sites that are hyperphosphorylated during the course of tau pathology in AD and show that certain β-carboline alkaloids can significantly reduce the levels of phosphorylated tau protein.