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In sensitivity analyses we looked at the course of function in patients with complete data without interpolation of HAQ showing similar results and a decrease of HAQ over time in remission.
When painful transcutaneous electrical stimulation and somatosensory evoked potentials were used to examine the time course of function for up to 35 minutes after 50% N2O inhalation, impairment lasted as long as 35 minutes afterwards and was as great as impairment during inhalation [ 18].
To enable early recognition of poor functional outcome, it is important to obtain more insight in functioning and the course of functioning in the defined group.
Other aims of the programme are to describe the "natural" course of functioning and development in CP, evaluate treatment methods and increase cooperation between health care professionals.
Further studies, based on longitudinal designs, should be carried out to determine the quality of life, participation levels and to identify the factors that predict the course of functioning in adolescents and adults with CP in the years ahead.
Computational challenges rise from simple sample processing, to assembly, binning, and identification of species; further challenges are annotation of genes and of course assignment of function.
The subjects received 450 mg of CF twice daily for 1 month to determine the time course of endothelial function by FMD, which measures endothelial function and is a prospectively validated surrogate marker of cardiovascular risk.
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