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In addition, as Figure 4b demonstrates, the time course of extinction between the two groups was virtually identical, with both NR and R mice decreasing their preference score from positive to negative in a similar fashion over the extinction period.
In contrast to previous reports, IL neurons exhibited CS-evoked responses early in extinction training in both immediate and delayed conditions and these responses decreased in magnitude over the course of extinction training.
In addition, we did not find statistically significant differences in time course of extinction or reacquisition.
Over the course of extinction, response bouts progressively shortened for WKY but not for SHR.
DBERM parameter estimation also demonstrated that bout length decayed over the course of extinction for WKY, but not for SHR.
These dynamic components allow for the dissociation of starting parameter estimates (which are dependent on maintenance conditions) from their rate of decline over the course of extinction.
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In addition to the bursting, we found that CS-evoked activity in the IL (at least among those neurons that exhibited an excitatory response to the CS) did not dissipate during the course of immediate extinction training, unlike that in rats undergoing delayed extinction.
Early on, Abraham Lincoln talked vaguely about putting slavery on "the course of ultimate extinction".
Instead he wanted slavery to be "put in course of ultimate extinction".
Lincoln's election to the White House meant, for South Carolina, that "the public mind must rest in the belief that slavery is in the course of ultimate extinction".
In his famous House Divided speech of 1858, Lincoln said that Republicans intended to "arrest the further spread" of slavery and thus place the institution "in course of ultimate extinction".
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