A friend of the physiologist Claude Bernard and an admirer of Charles Darwin's work on evolution, Morel sought explanations for mental illness in heredity, although he later came to believe that external agents such as alcohol and drugs could also affect the course of mental deterioration.
Although the course of patients' deterioration did slow somewhat, the decline was not statistically significant enough for FDA approval, Bowden concluded.
To determine more precisely the time course of clinical deterioration within this window, we next quantified the RMCBS at more frequent intervals (Figure 4).
Accurately identifying patients earlier in of the course of physiological deterioration should be expected to yield greater opportunity for rescue.
The success of the MET system relies on the assumption that early intervention in the course of clinical deterioration improves patient outcome [ 4].
That study was performed to describe the time course of metabolic deterioration in insulin pump patients after prolonged interruptions of basal insulin during the overnight period.
During the course of clinical deterioration, iron accumulation involving the substantia nigra and globus pallidus is evident as observed in brain imaging [ 5].
Through our findings and inference, the potential molecular mechanisms for the course of CIN deterioration are provided from eight aspects: inflammation, angiogenesis, cellular stress, apoptosis & proliferation, invasion & migration, virus infection, cell immortalization, and energy metabolism.
Most important, too few amyloid-positive subjects have been identified and followed longitudinally to give guidance to the patient regarding likelihood and time course of future cognitive deterioration.
Of course, deterioration can happen fast.
