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To determine the time course of activation and how AMPK could decrease mTORC1 activity over a hypertrophy time course, we assayed AMPKα1 activity at 3, 6, 9, 12, and 21 days and TSC2 phosphorylation via immunoprecipitation at Ser and Thr.
In case there were any doubt, plots of the time course of activation show clearly that this patient responded quickly to each question, activating the "tennis" or the spatial "navigation" task, with the activation dissipating when the patient was instructed to "relax".
A method for measuring the time course of activation from a selected volume of the brain.
Muller, H. J. & Rabbitt, M. A. Reflexive and voluntary orienting of visual attention: time course of activation and resistance to interruption.
The time course of activation and the shape of the action potentials in different parts of the heart are responsible for the synchronous activation and contraction of the muscles of the atrium followed by those of the ventricle.
The dose and time course of activation of caspases 3, 9 and 7 (Figure 1B) paralleled the progressive loss of BAG3 (Figure 1E).
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On the other hand, there also seems to be evidence for the latter, e.g.: good continuation and grouping by proximity acting independently when aligning collinear Gabors in pathfinder displays14,15, and reports of differences in the time course of activations of proximity and similarity grouping16,17,18, or similarity and collinearity19.
The other three sessions employed continuous imaging (8 functional images per block, TR 2.9 s, 23.2 s/block, interleaved slices) to permit the analysis of the time course of activations.
Time courses of activation were determined from these active voxels, and linear drifts were removed for each individual voxel.
While the time-course of activation changed with level, the change was subtle and only significant in a part of the cortex.
We also briefly discuss important temporal considerations, including appropriate timing of sample collections for hormones with different time-courses of activation (e.g. ACTH vs. cortisol), the pharmacokinetics of both endogenous hormones and administered agents, and circadian considerations.
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