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While the clinical course is usually benign, complications such as encephalitic involvement resulting in a more severe clinical course may occur.
Instead, a fluctuating course may occur with some patients having improvement with time [ 4, 5].
ADEM, which typically follows a monophasic course, may occur in any age group, especially in children, but cases in children under 3 years old are rarely reported.
In HIV hepatitis B virus coinfected patients, an acute hepatitis flare (with potentially fulminant course) may occur post-ART initiation, and may be difficult to distinguish from ART drug toxicity.
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In individual cases with renal failure, severe and lethal courses may occur despite a CPDG2 application, in particular if delayed CPDG2 administration did not prevent overt toxicity.
Another feature of type I hypersensitivity reactions is that, once the immediate local reaction to the allergen has taken its course, there may occur an influx of more granulocytes, lymphocytes, and macrophages at the site.
However, such a change as a result of in-course practices may occur in less advanced students, such as those enrolled in introductory biology, who are the target audience of our future studies.
Besides negative experiences of breast cancer in the family (e.g. extensive treatment or loss of a family member), positive experiences during course of treatment may occur yielding positive effects on psychological distress.
On the other hand, as shown by others, loss of anti-topo I reactivity during the course of the disease may occur in up to 20% of the patients [ 12], suggesting that a simultaneous assessment could be important.
The trajectory includes the day-to-day health fluctuations, or 'good days' and 'bad days', super-imposed along the larger course of disablement that may occur over months or years of living with HIV.
During the course of trials unintended pregnancy may occur, especially in trials where long term follow-up is being assessed.
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