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Of course, deterioration can happen fast.
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The hypothesis underlying this approach is that early intervention in the course of deterioration improves outcome.
Both hsCRP and IL-6 levels were associated with insidious psychosis onset, duration of illness and chronic schizophrenia course with deterioration.
Additionally, there was a higher level of serum IL-6 among patients with schizophrenia characterized by chronic course with deterioration in comparison with the schizophrenic patients with multiple episodes with good or partial recovery or even with chronic course; however, without marked deterioration of functioning (p = 0.01) (Fig. 1).
A friend of the physiologist Claude Bernard and an admirer of Charles Darwin's work on evolution, Morel sought explanations for mental illness in heredity, although he later came to believe that external agents such as alcohol and drugs could also affect the course of mental deterioration.
Although the course of patients' deterioration did slow somewhat, the decline was not statistically significant enough for FDA approval, Bowden concluded.
To determine more precisely the time course of clinical deterioration within this window, we next quantified the RMCBS at more frequent intervals (Figure 4).
Her subsequent clinical course showed rapid deterioration, and she was treated with alemtuzumab, but unfortunately, she relapsed quickly.
Accurately identifying patients earlier in of the course of physiological deterioration should be expected to yield greater opportunity for rescue.
The success of the MET system relies on the assumption that early intervention in the course of clinical deterioration improves patient outcome [ 4].
That study was performed to describe the time course of metabolic deterioration in insulin pump patients after prolonged interruptions of basal insulin during the overnight period.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com