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Of course, concurrent administration of vaccines is desirable only when immunogenicity is not adversely effected, and safety is similar or improved.
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This approach is more easily and safely obtained by dose-escalating long-course concurrent chemoradiotherapy.
Two phase III trials have directly compared short-course preoperative radiotherapy followed by immediate surgery versus long-course concurrent chemoradiotherapy followed by a delay in surgery.
Four chemotherapy courses concurrent with radiotherapy (courses 5 to 8) were administered days 43, 50, 64 and 71 with the ninth week used as a rest week.
A time course of concurrent cerebrospinal fluid (CSF) and plasma samples were taken following administration.
Subthreshold GAD was also seen to worsen the course of concurrent somatic diseases [ 50].
All 41 patients completed a total dose of 60 Gy radiotherapy immediately after HBO with one course of concurrent chemotherapy.
This possibility does not of course exclude concurrent primary involvement of the speech output mechanisms proper (indeed, that would be anticipated with a neurodegenerative process).
Additionally, both HF and FS can adversely affect the course of concurrent diseases, and increase the risk of falling, disability, hospitalization, and death.
All 41 patients were able to complete a total radiotherapy dose of 60 Gy immediately after HBO with one course of concurrent chemotherapy.
With regard to chemotherapy, all 41 patients could receive one course of concurrent chemotherapy, and 33 of 41 (80%) patients received further chemotherapies.
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