Since LID always firstly emerged on the side that was most affected by Parkinson's disease, we extracted coupling values of the most affected hemisphere of each individual patient.
Because of the coupling relationship between the transmitter and the receiver, even if an intruder knows the coupling values of the system, he could not steal the message from the system from practical simulation results.
This angle predicts average J scalar coupling values of 5.0 and 1.4 Hz for all n P– n H5′ and n P– n H5″ torsions, respectively (Table S13 of the Supporting Information).
Entering coupling values of 'feedback' connections from putamen to preSMA (P corrected = 0.020) and M1 (P corrected = 0.044), respectively significantly improved the proportion of explained variance in individual LID scores as opposed to a model only containing modulation of neural activity.
Circles represent observed contact prediction accuracies, solid lines, a fit to a sigmoid function of the normalized coupling value, the number of sequences, the length, and the sequence separation (see Figure 16 figure supplement 1 and Figure 16 figure supplement 2).
While the interpretation of these J coupling values in terms of a three-site rotamer hopping model is generally justified, there are clear cases in which the predicted minor rotamer is not sterically feasible, as was observed also for ecDHFR.
Contact prediction accuracy was found to be a simple function of the residue residue normalized coupling value, the number of sequences, the length, and the sequence separation as shown in Figure 16.
We calculated the changes of the evolutionary coupling values (ΔΔE) of each individual Pak2 residue caused by perturbation at moderately conserved Thr402 (34.6%).
To analyze the evolutionary coupling effect on one residue, we mutated the particular residue in silico and measured the evolutionary coupling values (ΔΔE) of each individual Pak2 residue.
