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GPCR activation may therefore involve receptor desensitization, coupling to multiple G proteins, Gα or Gβγ signalling, and pathway activation that is independent of G proteins.
LPAR2 can initiate intracellular signaling via coupling to multiple Gα subunits from the Gi, Gq, and G12/13 family of heterotrimeric G-proteins (Choi et al., 2010).
In particular, because in our model the promoter's expression is a linear function of the regulatory inputs, the theory extends easily to promoters coupling to multiple regulators with different coupling constants.
We propose a controllable and scalable architecture for quantum information processing using a superconducting system network, which is composed of current-biased Josephson junctions (CBJJs) as tunable couplers between the two superconducting transmission line resonators (TLRs), each coupling to multiple superconducting qubits (SQs).
These are just a few of the many examples of GPCRs coupling to multiple G proteins.
This multitude of activities is consistent with the broad distribution of LPA receptors and their coupling to multiple G proteins.
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While much of the work to date has focused on systems in which there is a single qubit, and there is a growing literature on the case of two qubits [10, 17, 19, 41, 44 49], an important future direction for both fundamental effects and possible applications is to study a waveguide coupled to multiple (or many) qubits.
In a processive mode of enzymatic catalysis, a single substrate binding event is coupled to multiple rounds of catalytic turnover.
The nanocrystal-ssDNA conjugates were purified away from uncoupled gold nanocrystals, and from gold nanocrystals coupled to multiple ssDNA strands, by ion-exchange HPLC (Dionex, DNAPac PA-100) and stored at −20°C (Fig. S2).
CD95 is coupled to multiple potentially tumorigenic signaling pathways.
This mode of cell death results from a bio-energetic and metabolic catastrophe coupled to multiple active execution mechanisms.
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