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Adhesion substrates significantly altered myotubes stiffness, measured by Atomic Force Microscopy, and differently affected the cells Ca2+ handling capacity and the maturation of excitation-contraction coupling machinery, evaluated by Ca2+ imaging.
In striated muscles, invaginations from the plasma membrane, termed transverse tubules (T-tubule), function in the excitation contraction coupling machinery.
The uneven density distribution of dihydropyridine receptors indicates a difference in E-C coupling machinery between muscle fibre types.
Changes in E-C coupling machinery may act as causative factors for, or adaptive mechanisms in, muscle aging that directly contribute to muscle weakness.
Here we characterized for the first time CRAC channel inhibitors which exert their action downstream of the STIM1 Orai coupling machinery, since they leave STIM1 oligomerization and STIM1 Orai1 interaction unaffected.
The effects genetic interventions have on the function of the mouse E-C coupling machinery have been evaluated on the basis of the analysis of the phenotypes of the animals bearing the genetic modifications.
Similar(47)
Chromatin features can directly affect splicing outcome by physically coupling the transcription machinery with the splicing apparatus via chromatin-binding adaptor proteins.
Though there has been some progress in elucidating ATP release mechanisms of some mammalian cells types, release conduits and coupling signal transduction machinery remain larger elusive for leukocytes.
Vinculin binds and recruits the Arp2/3-complex to cell membrane, thereby coupling the actin machinery to the adhesion sites and enabling lamellipodia protrusion.
Indeed, the regulation of these enzymes provides a novel cell cycle dimension to the completion of homologous recombination, in that they have become key targets of the mitotic and meiotic cell cycle machinery, coupling the completion of DNA repair to the initiation of chromosome segregation.
Thus, these results suggest that defects in the excitation contraction-coupling machinexcitation contraction-couplingLmachinerygenesis and that a functional link between maytubularindeed amphyphisin 2 exists in skeletal muscle.
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