Our data suggest that this sequence modification coupled with structural modification differentially recruits human TLR8 over TLR7, and could have potential application in antiviral therapies.
Vascular changes associated with the aging process are progressive, involve hypertrophy and hyperplasia of smooth muscle cells within the vascular tree, coupled with the modification of matrix proteins, and may occur before hypertension begins [39].
Examples include the use of air filters (Francis et al. 2003; Kilburn et al. 2003), pest management (McConnell et al. 2003), and education coupled with environmental modification (Krieger et al. 2002; Morgan et al. 2004; Tobias et al. 2004).
The labeling protocol introduced for the single-molecule analysis of replicated DNA [ 161, 162] can be coupled with proper modification of the method of microfluidic extraction and the stretching of DNA from single nuclei [ 163].
Given the current limited knowledge of the energetics of RNA loops and tertiary interactions, however, microarray binding data do not provide a reliable check on secondary structures deduced from free energy minimization coupled with chemical modification constraints when the RNA has short helices and large loops.
Chemically-induced band gap variability (Eg ∼ 1 eV) coupled with structure-modification indicates the electronic-structure changes in Ga-Mo-O.
Structure-based protein engineering coupled with chemical modifications (e.g., pegylation) is a powerful combination to significantly improve the development of proteins as therapeutic agents.
The CALERIE intervention employed an intensive behavioral approach coupled with dietary modifications anticipated to enhance adherence to CR. Intervention staff included psychologists and nutritionists who provided individual and group counseling and utilized a centralized interactive database to monitor interventionists' practices and participant adherence over the course of the study.
DNA methylation, coupled with histone modifications, would affect the interactions of the promoters of critical genes with transcriptional corepressors and coactivators leading to changes in gene expressions, which could be one of the driving forces for prostate carcinogenesis.
