Herein, we demonstrate that the glycosyl linkage stereochemistry of the pendant aminofucosyl group plays a pivotal role in binding, and coupled with insight obtained with various bulged targets, will allow rational design of second generation ligands.
I want unrestrained optimism and audacity coupled with insight and paranoia.
Unambiguous identification of a natural metastable protein assemblage may require more comprehensive calculations coupled with insight gained from experiments and observations in the field.
This, coupled with insights from deep sequencing, robust neutralization assays, and other technological advances, is spurring research toward rationally HCV designed vaccines that preferentially elicit responses toward conserved epitopes of interest that are associated with viral neutralization and clearance.
The grueling testimonies from CEO John Stumpf, coupled with insights from my industry-wide research into the culture and mindsets of bankers, suggest there is a blind spot among senior leaders at Wells Fargo, as well as deterrents to speaking up among the rank and file.
Here, political economies focus on social structures and economic systems as the key determinants of inequality is coupled with insights from constructivism that emphasizes the role human agency and culture play in producing differential vulnerability among individuals and groups (Calgaro 2010).
Coupled with insights gained from planners involved in the planning process and from government officials from the Southern District Planning Administration Office at the Ministry of Interior, the analysis seeks to reveal the changing ideals and planning policies that had shaped the physical layout of the towns.
Coupled with insights from the wider literature on improvement and organisational change, they provide some important messages about what is likely to work in improving the quality of health services and what pitfalls to anticipate.
The past few decades have witnessed creative and ingenious ways of examining infants in order to appreciate what they are learning and if they remember, coupled with insights from surface ERP recordings of cortical responses.
Inspection of the primary sequence surrounding BH-HN, coupled with insights obtained from molecular dynamic (MD) simulations [ 34- 36], provide a plausible explanation for the structural basis of the BH-HN hinge.
However, the greater understanding of the diagnosis and symptom profile exhibited by the patient, coupled with insights into the epidemiology, management and potential future developments have established Cough Hypersensitivity as the most accurate and convenient diagnostic grouping for patients suffering with chronic cough.
