The overwhelming evidence for redundancy in pain mechanisms coupled with a simplistic classification of nociceptive mechanisms on the basis of early electrophysiological studies helps to explain recent problems in developing analgesic drugs.
A non-linear parameter optimisation algorithm was coupled with a relief classification scheme to optimize four classification parameters with regard to environmentally sensitive landforms: shoulder and footslope.
Principal components analysis coupled with a cluster classification method and spatial overlay techniques were used to identify two hierarchical levels of landscapes.
The weighted bags of visual words representation is coupled with a discriminative method to perform classification.
A similarity measure was coupled with a -nearest neighbors algorithm to perform classification.
A polytomous logistic regression could be coupled with the classification model to include predictors of group membership, such as the type of mole.
Analysis of phylogenetic profiling coupled with functional classification identified translation (J), cell wall biosynthesis (M), and cell motility (N) to each contain distinct affiliations that may help differentiate between the two opposing Aquificae hypotheses (fig. 1).
AutDB coupled with PhenoBase affords structured classification of a heterogeneous profile such as the phenotype data of mice.
With regard to the species-specific miRNAs, they can be predicted depending on the intragenomic matching between miRNA candidates and their targets coupled with support vector machine classification of miRNA precursors.
The lack of a general consensus on the classification of Symbiodinium species coupled with the variety of different markers used to identify the genus Symbiodinium (ITS1, ITS2, LSU D1/D2, chloroplast 23S rDNA and psbA minicircle) further complicate direct comparison.
Improvements in trial design, including development of consortia for the conduct of national and international multicenter studies and use of standardized classification and outcome measures coupled with the emergence of newer biologic, immunomodulatory, and small molecule agents, hopefully will result in the addition of disease-modifying agents to the armamentarium.
