All additional information about the sequence including but not limited to the nucleotide sequence (or color space sequence in the case of SOLiD data), quality values, SNP locations, mate pair information and meta data are stored as feature data coupled to the sequence, with general and configurable methods for how to visualize different categories of feature data.
Accordingly, the development of integrated algorithms for designing feasible primer sets for entire mt genome sequences coupled with the sequence alignment are still challenging.
The relatively low statistical support for many CydX homologues likely reflects the small size of the protein coupled with the sequence diversity observed between homologues.
By coupling the coding sequence for PXR to its cognate human proximal promoter (termed pPXR-PXR) it is possible to examine the role of transcriptional level control of PXR expression on the activation of downstream target genes such as CYP3A4.
For stable cohabiting couples, the sequence of first birth and marriage does not matter as much as the act of marrying itself.
Restiction site mutation couples the sequence specificity of restriction enzymes to the amplification power of PCR in order to 'fish out' low-frequency mutated p53 sequences from among excess nonmutated sequences.
Characterization of multiple natural product biosynthetic pathways from these organisms coupled with the sequencing of two model strains (Myxococcus xanthus and Sorangium cellulosum) has significantly deepened our understanding of the genetics, biochemistry, and regulation of secondary metabolism in these microbes.
Here, we show that the minor and major groove dimensions in DNA are intrinsically coupled to the sequence-dependent BI and BII phosphate group conformations.
This, coupled with the sequencing of the human genome and the subsequent abundance of molecular biology techniques to support both research and, increasingly, diagnosis, highlights the need to develop approaches for exploiting FFPE archives.
Thus, coupled with the sequencing of the A. thaliana genome, these efforts have provided data on only a single branch of the plant evolutionary tree, namely members of the Monocotyledonae and Dicotyledonae, collectively termed the angiosperms and commonly known as flowering plants.
