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While insufficient to explain the stronger regulation displayed by some of the target mRNAs of these RBPs, these mRNA-level changes could synergize with other modes of cell-cycle coupled regulation of these RBPs (e.g. phosphorylation, degradation) to maintain tighter coordination between cell cycle phase and the expression of their downstream target transcripts.
Due to the highly coupled regulation of flux and concentrations in metabolic networks [ 28], it is not surprising that the MINLP-based formulations, especially the flux based R-DFBA and R-DFBA CF, outperform the rest of the investigated approaches.
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As discussed below, coupling regulation of different physiological properties may be beneficial from an energy conservation point of view, and/or it might reflect common signaling systems diverging to regulate several sets of diverse genes.
The most common set of phenotypic categories is "regulation of extent of cell growth", coupled with "regulation of intracellular signal transduction" and "cell surface receptor signaling pathway".
Sorkin says that executive compensation needs to be coupled with regulation to change the "ethos" of Wall Street.
In the retinal progenitor cells, differentiation decisions are coupled to regulation of cell cycle.
CSBP II consists of several proteins, some of which are differentially phosphorylated over the cell cycle [15], suggesting a likely mechanism for cell-cycle coupled transcript regulation.
These findings are based on the premise that conservation in the noncoding regions is coupled with regulation of genes, thus implying that the conservation could necessarily be due to a functional constraint.
However, the risk of PSN is also increased by advancing age and affected by height and possibly by sex (3) and poorly defined factors, such as processes coupled to regulation of IGF-1 (4, 5).
This we propose is achieved through the development of post-translational processes, which serve to partly de-couple regulation from transcription.
Interestingly, ANXA6 down-regulation is accompanied by an increase in SERCA1 expression levels, which is probably related to the modulation of the events involved in excitation-contraction coupling (regulation of muscle contraction – GO 0006937).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com