Finally, activated neutrophils from naive mice were also able to induce T cell death, albeit to a lesser extent than tumour-elicited neutrophils, suggesting that, in general, neutrophil activation is counterproductive to T cell function.
Current approaches in developing novel anti-HER receptor targeted drugs that block the entire type 1 RTK family via 'pan-HER' blockade [ 59] may be counterproductive due to the ambivalent function of HER4.
Analogously to its structural mechanic archetype, their fluid dynamic topology optimisation starts from a completely flooded computational domain (Figure 4), uses some local criterion to identify those areas that are counterproductive w.r.t. the chosen objective function and iteratively 'punishes' or removes them from the fluid domain.
However, Figure 1 suggests that increasing the role of electrostatics by adaptations to the CNS energy function may be be counterproductive, while decreasing this weighting would only reduce its already minor effect.
Ignoring conceptual questions about how technologies attain their meaning and function can lead to a counterproductive design strategy because crucial influences on how technologies are shaped within actual practices are ignored.
Accountability is the foundation of any relationship, and without it, the function of my work is counterproductive.
Sessions are more frequent, such as weekly or bimonthly; lengthier (often an hour); and focus more intensively on individual and family processes deemed counterproductive to optimal disease care and family functioning (15, 16).
We find that the pay ratio rule is ineffectual and potentially counterproductive in fulfilling an informational or a behavioral function due to its low informational integrity – the inherent lack of accuracy, difficulty in interpretation, and incompleteness of the information.
Trimming, revising or eliminating programmes that are ill-conceived and counterproductive would both free up resources for essential functions and improve the efficiency and effectiveness of FDA regulation.
Especially for the function in excision repair a specific binding site seems counterproductive to the occurrence of mutations only by chance not at specific sites.
Many projects produce change in one aspect of an organization's functioning that does not last or that proves counterproductive because it doesn't mesh with other aspects of the system.
