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26 The inability of ACCORD, ADVANCE, and VADT to demonstrate significant reductions in CVD outcomes with intensive glycemic control also suggests that current pharmacological tools for treating hyperglycemia in patients with more advanced T2D may have counterbalancing consequences for the cardiovascular system.
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Obviously, as long as the intimate mechanism linking Aif depletion and impaired complex I deficiency is not fully depicted, this model will be best used to test for efficiency of compounds/strategies aiming at counterbalancing the consequences of complex I deficiency.
Every decision we make has a footprint and we should be aware of if what we are bringing in is going to have enough impact as to counterbalance its consequences.
In contrast to BN, recurrent inappropriate compensatory behaviours to counterbalance the consequences of bingeing are absent, for this reason patients with BED are frequently obese.
To counterbalance the consequences of a low neutrophil count, the use of granulocyte colony-stimulating factors (G-CSFs) has been extended, limiting the risk of infection and maintaining the chemotherapy dose intensity if its reduction may compromise efficacy (Smith et al, 2006).
Insurance is desired to counterbalance the negative consequences of unexpected events, like illnesses or natural disasters.
To examine whether or not the assignment of a given handle shape to a force field was of any consequence, counterbalancing was included as a between-subjects factor.
A number of authors have written about the benefits of on-the-job learning [ 19, 20] but others have emphasized that such practical experience should include role modeling and critical reflection in order to counterbalance the potential negative consequences of the medical curriculum on attitudes towards immigrant and other underserved populations [ 21].
A consequence of this counterbalancing procedure is that the novel object in any given pair is reversed; for example, for half of the rats in the trial of B versus C, it is C that is novel (see above), but for the other half, it is B that is novel.
Third, it is possible that the adverse consequences of duty hour reduction will counterbalance any beneficial effects of reduced fatigue.
The notion that autonomic neuropathy results in a defective counterbalance towards rosiglitazone-induced vasodilatation and subsequent vascular leakage has two consequences.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com