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Assuming that FasL-positive tumour cells interact with tumour-infiltrating lymphocytes, our clinical data support indirectly the counterattack model.
The latter role has prompted the establishment of the controversial 'tumor counterattack' model, which suggests that FasL expression by tumor cells would kill Fas-sensitive effector cells of the immune system.
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Appropriate counterattack schemes for this model are also left as a future work.
The increase in the incidence of adenoma development and the invasiveness of these adenomas, paralleling a decrease in Fas-L in these mice, does not support the Fas counterattack notion in this model.
These proteins can act at different stages of the "zig-zag" model of attack and counterattack between plant and pathogen [ 2], and a combination of different proteins could act synergistically in defence against pathogen attack.
A series of counterattacks by Army Group B under Field Marshal Model kept Horrocks' units on the defensive, and delayed their advance by forcing the British to halt and secure their flank.
Additionally a further feature of tumor immune escape mechanisms, the FAS/FAS-L "counterattack", could be shown in the described murine model.
These counterattacks usually failed to recover ground, but they kept the Soviets off-balance and won Model time to pull his units back.
Model believed that the situation represented not just a threat, but also an opportunity to counterattack and possibly clear the Allies out of the southern Netherlands.
We counterattack.
The counterattack worked.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com