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Plant ROS production is nevertheless partly effective in counteracting disease progression since an AtrbohD-AtrbohF double mutant is more susceptible to the bacterial infection [27].
All these treatments provided variable metabolic correction and pathological amelioration but were overall modestly effective in counteracting disease progression, failing to address the global disease.
3xTg-AD mice when compared with age-matched WT mice, a finding that supports the hypothesis that aged 3xTg-AD mice may show deficits in counteracting disease progression.
Whether it will allow monitoring of the disease course or the response to various treatments aimed at counteracting disease progression remains to be studied.
The vast majority of SMN1-deleted SMA patients carrying two SMN2 copies suffer from type I or II SMA, while only few patients (∼2%) develop a mild (type III SMA) phenotype (9), suggesting the existence of a yet unknown factor counteracting disease progression.
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The data provide evidence for a repair mechanism to counteract disease progression.
Assessment of neurocognitive performance at diagnosis may offer the opportunity to improve functioning in daily life and counteract disease progression.
Otherwise, irisin might exert a different function trying to counteract disease progression that is reflected in its expression levels.
The severity of ALS and the lack of effective therapeutic strategies are driving efforts to explore agents, applied either separately or in combination, to counteract disease symptoms.
For example a recent study of meal frequency from studies of animal and human subjects suggests that intermittent energy restriction can improve health indicators and counteract disease processes.
Hence, these observations support great interest to target the MIC-1 signalling cascade to eradicate AI, metastatic and chemoresistant PC stem/progenitor cells endowed with stem cell-like and EMT properties to counteract disease progression to metastatic CRPCs.
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