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The combination, at doses ineffective individually, even counteracted the development of lung oedema induced by sephadex in the rat.
Furthermore, administration of TRAIL significantly counteracted the development and extension of atherosclerotic plaques in an experimental model of atherosclerosis (apoE-null mice) [21].
Chronic treatment with a COX-2 inhibitor during the course of chronic stress counteracted the development of hedonic deficit, behavioural despair, increased anxiety and cognitive impairment in a similar manner to citalopram.
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To counteract the development of cancer, these organisms developed a number of cell extrinsic and intrinsic tumor-suppressing mechanisms one of which is cellular senescence, a proliferative arrest that forces cells to exit the cell division cycle permanently.
We previously demonstrated that ACE2 counteracts the development of severe ALI or ARDS induced by avian influenza virus, severe acute respiratory syndrome-coronavirus spikes, sepsis and acid aspiration in mice [16,17,18].
Consequently, the idea of tolerance implies the necessity, for the dissenting group or individuals, to become illegitimate if and when the established legitimacy prevents and counteracts the development of dissent.
A major challenge to counteract the development of resistance to antibiotic treatment is to get a better understanding of how bacteria react to antibiotics.
Furthermore, this increased oxygen supply might be beneficial as it counteracts the development of an anaerobic metabolism after trauma-haemorrhage, thereby preserving energy-rich phosphate (e.g. ATP) levels and attenuating a tissue energy depth.
In addition, the double mechanism of action could allow 4-oxo-4-HPR to efficiently target tumour and to eventually counteract the development of drug resistance.
A decrease in the oxidative phosphorylation capacity may counteract the development of diabetes, despite its deleterious effects on β-cell survival.
The ability of 4-oxo-4-HPR to act through at least two unrelated mechanisms could probably allow to counteract the development of drug resistance.
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