These findings raised the possibility that these ligands might counteract the ability of Aβ to decrease levels of AKT activation.
It was therefore important to determine whether nutlin-3 can counteract the ability of AML1-ETO to induce proliferation and self-renewal in primary human CD34+ cells.
In contrast to cells overexpressing LynWT and grown with Epo, the growth of 663-LynY397F cells in the presence of Epo was reduced compared with control cells indicating that the dominant negative Lyn mutant was able to counteract the ability of Lyn to favor Epo-induced proliferation (Figure 5D).
These results indicate that FGF8 counteracts the ability of Pin1 to induce ΔNp63α, degradation.
For example, an alternative explanation is that anti-angiogenic drugs prevent the rebound in tumour growth that may occur during breaks in chemotherapy [ 76] or counteract the ability of chemotherapy to promote tumour invasion [ 77].
This reduced α-helical disruption could be due to the combination of α-helix-destabilizing effects of phosphothreonine being partially counteracted by the ability of phosphothreonine to more effectively nucleate the shorter C-terminal α-helix (e.g., in residues 5 14, with strong α-helix nucleation by phosphothreonine at the N-terminus of the short α-helix, as seen above).
The study data are in agreement with previous reports, but education still remains a mediocre predictor of lower HRQoL, which could possibly be related to cultural perception of health and might also be counteracted by the ability of attaining a better paid occupation than education itself.
Furthermore, ECE-1a-conditioned media also counteracted the invasive ability of ECE-1c-transfected PC-3 cells, suggesting the possibility of a soluble factor in the conditioned media.
The results presented here support these previous findings of myosin-IIA as a key element in Mk regulation, demonstrating that inhibition of myosin IIA counteracts the ability of type I collagen to repress PPF in a physiological setting of the osteoblastic niche.
Here, we present evidence that intergenic transcription counteracts the ability of enhancers to stimulate the promoter of the target gene.
