Sentence examples for counteract the defect from inspiring English sources

The wealth of genome information has also led drug researchers to a new, seemingly backwards, approach: instead of choosing a disease, finding a gene defect associated with the disease and then trying to devise a drug to counteract the defect, some researchers now look for genes that appear amenable to drug treatment and then try to figure out what diseases those drugs might cure.

The study emphasizes the importance of Pi on red cell function and indicates that elevated Pi tends to counteract the defect in oxygen-release capacity of the erythrocytes in diabetes patients.

Purified blood components can be transfused to treat specific defects; for example, platelets are used to correct a low platelet count, and clotting factor VIII is given to counteract the clotting defect in classic hemophilia.

Although BPIFA1 has been implicated in regulating ENaC activity and airway surface liquid to counteract the CF defect (Garcia-Caballero et al. 2009; Rollins et al. 2010), the function of BPIFB1 in this location remains unknown.

To counteract the observed defect in catecholamine responses to hypoglycemia in those with long-standing type 1 diabetes, Cryer and colleagues (47) examined the ability of the β2-adrenergic agonist terbutaline to diminish the risk of nocturnal hypoglycemia.

As ENaC-mediated Na+/fluid absorption is increased in CF airways and because this abnormality contributes to airway surface liquid depletion, an important mechanism in the pathogenesis of CF lung disease (Mall 2009), it has been hypothesized that upregulation of BPIFA1 may counteract the basic defect and improve impaired airway surface hydration in CF (Garcia-Caballero et al. 2009).

This enhancement is consistent with a dose effect, and suggests that the level of wg activation in these silenced flies is inadequate to counteract the developmental defects caused by Mfl depletion.

Because RAD51 overexpression counteracted the cytotoxicity associated with BRC4 induction (Fig. 7), we tested if it may also counteract the DNA repair defects of BRC4-induced cells.

In doing so, they provide further proof that maintenance of intrinsic cellular polarity can effectively counteract the devastating proliferative defects associated with mutations in global signaling molecules such as Ras.

These evidences, allowed to hypothesize that the implementation of pharmacological treatments aimed to enhance the glutamate uptake or counteract the oxidative stress, produced by defects in its intracellular transport, may contribute to improve the symptoms observed in TBPH minus flies (19, 26).

Ms. Schepis, 31, was undergoing treatment to counteract the drug, which can cause birth defects.