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In a second step we tested the model whether TRY or CPC can counteract the activity of the activators.
The finding that TRY and CPC can compete with GL1 for binding to GL3 [ 14, 29] suggests that the inhibitors can counteract the activity of the activators at the protein level directly.
It is interesting to find such proteins in M. xanthus (mxan0575) and S. cellulosum (sce5955), however neither are they suppose to counteract the activity of ELKs nor expanded in the genomes and therefore not further discussed in this paper.
This inhibitory function of coronin factors to counteract the activity of NPFs may well explain the basal accumulation of F-actin that we (e.g., Figure 3) and others [21], [22] have observed in non-stimulated coronin-1A null T cells and also, remarkably, in coronin-1A null B cells* ([22]; our unpublished data).
Currently no drugs are available that specifically counteract the activity of preformed toxins, while toxin neutralization is a classical property of antibody-mediated immunity.
Understanding these mechanisms might indeed offer therapeutic perspective to counteract the activity of this oncogenic splice variant in breast cancers with poor prognosis.
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This means that the ethanolic extract of red peel and red flesh of our apple are "in vitro" about ten time more active than BHT in counteracting the activity of 5-lipoxygenase with a small difference between the two tested extracts for ethanol extract of peel more rich in total polyphenols and anthocyanins.
We showed that the EAL domain-containing PvrR response regulator counteracts the activity of RcsB on cupD gene expression.
Considering that S. cellulosum harbors 3.2 times more kinases than M. xanthus this high number supports the hypothesis that these proteins are counteracting the activity of ELKs in myxobacteria.
It thereby counteracts the activity of lipoxygenases, and can modulate inflammatory responses [ 87].
The unique RS1-encoded protein RstC is an antirepressor that counteracts the activity of the CTXf repressor, RstR.
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