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It has been shown to: 1) play a crucial role in the prevention of inflammatory diseases; 2) counteract deleterious effects of IL-1 members involved in insulin resistance and diabetes; 3) reduce hyperglycemia and improve β-cell function in type 2 diabetic patients [29], [114], [115].
The gut mucosa is exposed to various beneficial and modifying factors (e.g., healthy food, exercise) that can counteract deleterious effects of harmful challenges.
Therefore, we wanted to investigate whether the increased insulin sensitivity of TG mice could be able to counteract deleterious effects of high-fat diets even in the presence of obesity.
Naturally occurring osmolytes are low-molecular weight compounds that are utilized by biological systems as chemical chaperones to counteract deleterious effects generated from extreme physical conditions, such as high osmotic and hydrostatic pressures [ 15, 16], dehydration [ 17], and high or low temperatures [ 16, 18].
The polymorphic pattern exhibited by the more recent APS and HPS haplotypes could indicate the evolution of compensatory SNPs that counteract deleterious effects of low activity haplotypes [39], [43], [44].
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Supportive of our findings, van Beuningen and colleagues [ 13] demonstrated that, in vivo, TGF-β also counteracted deleterious effects of IL-1 on cartilage PG synthesis and PG content.
Also, the effectiveness of HBE and quercetin was validated, to counteract the deleterious effects induced by C. d. terrificus venom, on cell viability of mouse brain slices.
Not only do these internal struggles diminish the probable efficacy of potential solutions to the brain drain, but they also negate the perceived responsibility of the countries receiving these migrants, diminishing their will to help counteract the deleterious effects of the brain drain.
Antioxidants are known to counteract the deleterious effects of ROS.
Previous researches demonstrated that the interaction of SA with SNP could counteract the deleterious effects induced by NaCl (Simaei et al. 2011).
Such work may confirm the therapeutic activities of dual TGF-β/sox9 gene transfer via rAAV and the advantageous delay in hypertrophic differentiation in vivo as mediated here by SOX9 in vitro (as discrepancies may occur in vivo) to counteract possible deleterious effects of TGF-β occurring upon direct gene transfer (osteophyte formation, fibrogenesis) (Bakker et al. 2001; Mi et al. 2003).
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