Consequently, anti-E2s could sensitize cells for these therapies.
Both, preincubation with TRAIL as well as chemotherapeutic drugs could sensitize cells for apoptosis induction by the other respective trigger.
We found that, despite the reduction of antiapoptotic Bcl-2 protein levels that could sensitize cells for death programs, TAT-NBI1/erlotinib-induced caspase-dependent cell death occurred without activation of the intrinsic apoptotic pathway, as witnessed by the low levels of Cyt c release and the absence of caspase-9 activation.
Moreover, the AR gene is amplified and/or overexpressed in about 30% of the hormone-therapy refractory tumors, and it has been proposed this could sensitize the receptor for the residual androgen concentrations and antiandrogens present under hormonal therapies [6], [7], [8].
It has been reported that modification of UCP2 could sensitize certain cancer cell for chemotherapy in leukaemia cells [ 21].
In the following, we elaborate on a few theoretical notions on the possible teleconsultation technology-user relationships that could sensitize us to meaningful events for future studies.
Finally, the intracellular pathways for many inflammatory mediators could sensitize TRPA1 in injured skin, contributing to channel activity and impairing the TRPA1 desensitization, thereby enhancing peripheral inflammatory responses via the production of other inflammatory mediators.
Next, we examined if analogs of staurosporine, PKC 412 and Ro 31 8220, could sensitize NSCLC cells to IR. Indeed PKC 412 was demonstrated to sensitize for RT and triggers mitochondria-mediated apoptotic response although Ro 31 8220 did not and instead increased survival signaling.
In vitro drug sensitivity assay revealed that suppression of NDRG2 could sensitize Hela cells to cisplatin.
Since p53 14/19 retains its transactivation capability and induces greater apoptosis than p53 22/23 in both HT1080 and SJSA cells, we selected p53 14/19 for further investigation to determine if it could sensitize cells to apoptosis caused by doxorubicin or cisplatin.
