Sentence examples for could sensitize a from inspiring English sources
We used the tet-off system to test the hypothesis that a transient and reversible reduction in gene expression could sensitize a promoter to undergo silencing.
It was reported recently that resveratrol could sensitize a number of cancer cells to the antitumoral effects of some conventional chemotherapy drugs.
Moreover, the evolution of resistance to one antibiotic could sensitize bacteria against a second antibiotic (Szybalski and Bryson 1952).
6, 40 It is controversial whether or not metal plates utilized in orthopedic surgery could sensitize or exacerbate a pre-existing nickel allergy and even lead to rejection of the hip replacement.
Treatment of TRAIL resistant hepatocellular carcinoma cells with specific kinase inhibitors or known chemotherapeutic drugs revealed that both classes of agent could sensitize to TRAIL in a caspase-dependent manner [18].
Taken together, these data strongly suggest that modulation of the cell cycle by treatment of SST could sensitize chemotherapy, both in a gallbladder cancer cell line and gallbladder cancer xenografts developed on nude mice.
DOI: http://dx.doi.org/10.7554/eLife.01236.034 There are no known small molecules which specifically inhibit NRF2, but we could test whether PERK inhibition could sensitize cells to death using a newly described small molecule PERK inhibitor, GSK2606414 (Axten et al., 2012).
Furthermore, in our previous studies, we showed that bortezomib, by inhibiting the CIP2A/PP2A/p-Akt pathway, could sensitize hepatocellular carcinoma cells to an antihuman death receptor 5 antibody, CS-1008 [ 48], and could enhance radiation-induced apoptosis in cervical cancer and hepatocellular carcinoma cells [ 52].
Next, we examined whether miR-34 restoration could sensitize the pancreatic cancer cells with a high level of endogenous Bcl-2 expression to chemo- and radiotherapy.
The current study demonstrates that EGCG could sensitize breast carcinoma to taxol in a murine model.
We therefore investigated whether miR-34 restoration could sensitize gastric cancer cells with high a level of Bcl-2 to chemotherapy.
