Next, we wished to determine whether the L32 TOP element alone could confer responsiveness to eIF4E independently of the downstream 5'UTR sequence.
Indeed, it will be important in future studies to examine whether similar changes in opioid receptor signaling occur in the brain after chronic ethanol consumption as we see in the spinal cord, since these changes this could effect responsiveness to naltrexone treatment.
Alternatively, more accurate measures of malaria incidence could enhance responsiveness of health systems to malaria epidemics.
In addition, E2 treatment increased concentrations of CXCR4 mRNA in isolated uNK cells, which suggests that E2 could enhance responsiveness of uNK cells to CXCL12.
For example, in a study from Bangladesh, it was suggested that helminth infection could reduce responsiveness in the QFT-GIT [ 29], in contrast to the results reported here.
To investigate whether E2 could increase responsiveness of uNK cells to chemoattractants, the expression of the CXCL12 receptor (CXCR4) and the IL-15 receptor alpha (IL15Ra) was assessed in uNK cells by qPCR.
This increased PAP responsiveness could be responsible for magnifying the effects of training, as the control group would remain in the same training state, responding similarly to PAP.
In that study, neither methacholine nor adenosine responsiveness could predict the response to a four-week treatment with inhaled fluticasone among 43 patients with chronic cough [ 7].
However, more comprehensive measurement is often tied up with less sensitive assessment in specific domains as shown in various studies: In the assessment of shoulder arthritis, a dose-response curve of specificity and responsiveness could be empirically proven [ 4].
With regard to the likely cause of the impaired hormonal responses, chronic exposure to stress could decrease the responsiveness of hypothalamic pituitary adrenal (HPA) axis [1, 4, 7 12].
