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And the fallout could prove substantial for some on the new list.
The new Basel rules' impact on JPMorgan's credit bets could prove substantial, which the bank's chief executive, Jamie Dimon, indicated last week in his Congressional testimony.
When I was chair of the Association of Art Historians, we obtained legal advice to the effect that any action by someone who claims to hold copyright on a work of historic art would be successful only if they could prove "substantial damage".
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Vonage's just-released data did hold out the hope that, as the company matures, its margins could eventually prove substantial.
But the powers of the federal government are limited in this area; DOMA has not stopped a few states introducing gay marriage and many more recognising gay civil partnerships.The damage done to a Romney presidency by his courting of the isolationist right in the primaries could prove more substantial.
But, if the links prove substantial, it could one day be a cheap and easy solution to give selenium supplements to help women extend their pregnancy.
Fred Hu, an economist at Goldman , Sachswith strong political connections in Beijing, said an agreement appeared likely soon and could make a big difference to Hong Kong's economic future if China's trade concessions prove substantial.
Four: Structural obstacles may prove substantial.
Moreover, potential risk factors which can be modified at an early stage of the disease, i.e., pain coping strategies or quadriceps strength, could prove to have substantial benefit in the treatment of patients with knee OA.
And if the federal government ultimately finds itself forced to seize and liquidate vast pools of troubled assets quickly, as in the aftermath of the savings and loan crisis, online loan auctions could prove effective in drawing substantial capital.
It could prove a hugely significant victory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com