This is due to the fact that prior anti-TB exposure provides only to suppress the growth of susceptible bacilli, but on the other side, it could permit suitable circumstances for the multiplication of pre-existing drug resistant mutants [ 12].
The ability to form and interconvert between isoforms (zero, one, and two unpaired nucleotides opposite the slip-out) could permit sufficient competition for repair outcomes, thereby weakening the ability to detect products of non-nick-directed repair.
Although the relatively small sample size of our own study does not allow for a systematic data-driven investigation of the possible determinants of between-subject variability, larger studies in the future might identify possible predictors of treatment response, which could permit patient selection for targeted treatment.
For example, greater sampling density in rodents could permit comparative analyses to test for positive selection, and subsequently test for gene-phenotype associations.
A better understanding of the hemodynamic effects of esmolol could permit a better timing for the initiation and to monitor treatment or to assess the eligibility of patients for this therapeutic strategy.
A growing list of antioxidant enzymes, including Prxs, are themselves subject to redox regulation, which could permit localized accumulation of H2O2 for signaling while simultaneously limiting the range of H2O2 diffusion.
Harrison (1977) suggested that "this slow expenditure of reserve metabolites could permit the orchid seedling to survive for a longer period until an appropriate endophytic infection is established".
For example, duplication could permit each copy of a multifunctional protein to specialize on a subset of the ancestral activities, thereby reducing pleiotropy [ 23, 24].
Only structures 1 and 2 could permit environment adaptation to be useful for training tasks, since only in these structures are the parameters modified by environment adaptation also used for tasks (see Figure 1).
This approach can enable more rapid trial closure or acceleration than trials focusing on a specific disease site, depending upon patient response rates, and could permit FDA consideration of a drug for approval in multiple disease sites [ 20].
