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The ubiquitin-proteasome system (UPS) functions in cellular quality control by degrading misfolded, unassembled, or damaged proteins that could otherwise form potentially toxic aggregates.
Inhibition at this step can suppress metastasis progression by preventing invasion through the basement membrane in the primary tumor, or adhesion and migration of circulating tumor cells that could otherwise form metastases. Mir-125a is capable of inhibiting Fyn and RhoA, kinases involved in promoting cell adhesion and invasion through cytoskeletal re-arrangements and integrin signaling [ 74].
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It has been demonstrated that mouse embryonic carcinoma cells, which otherwise form tumors upon subcutaneous injection, could develop if injected into blastocysts (Brinster 1974).
To do otherwise could risk forming a passive partnership with destructive and uncompromising currents within this strategically important country.
Add the dhoklis one by one into the dal, otherwise they could coagulate to form one big lump.
Furthermore, reaction 41 in [ 5] (42 in Additional file 13), threonine to glycine, was set to be reversible, as otherwise no biomass could be formed, and also reaction 61 in [ 5] (66 in Additional file 13), the citrate exchange reaction, was considered reversible.
Unlike classical pharmacological treatments, the use of progenitor cells could potentially restore functional tissue in regions that otherwise would form only scar.
The ability to "glue" protein layers, where otherwise no direct protein protein interactions could be formed, makes POMs additionally attractive for protein crystallization.
Otherwise, the form is clear.
No reader could feel otherwise.
Of course it could be otherwise.
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