Eugenol, a frequent sensitizer, does not sensitize CYP1A1 knockout mice, whereas the wild-type mice are sensitized to eugenol.
However, a role of CDK7 in mediating TRAIL resistance could be excluded, as CDK7 knockdown did not sensitize to TRAIL-induced apoptosis.
This suggests that most of the Er3+ ions in the low-temperature annealed specimens may be optically inactive and thus could not be sensitized by LCs (WOBs and Si = O states); in other words, high-temperature annealing is required to activate Er3+ ions.
Furthermore, they could not be sensitized to DNCB and their skin test to tuberculin was negative.
Importantly, untransformed human fibroblasts with reduced Mps1 levels could not be sensitized to sub-lethal doses of taxol.
However, CD40-stimulated CLL cells could not be sensitized to Compound A with ABT-737, indicating that induction of pro-survival Bcl-2 family members by CD40 stimulation does not mediate resistance to Compound A in CLL cells.
Similar enhancement of apoptosis (>40% at 24 h) was seen in A-375 and Mel-HO, when BMS-345541 was combined with an agonistic CD95 antibody (CH-11, 50 ng/ml; Figure 2c), but CH-11-resistant cell lines could not be sensitized (data not shown).
Lithium does not sensitize normal neuronal stem cells to radiation.
Inhibitors of AKT activation did not sensitize ACHN cells to TRAIL (data not shown).
