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In a phase I study using a low starting dose of 2.5 mg, and escalating 5 mg each 28 days to 10, 15, and 20 mg, one-third of patients could not escalate beyond 2.5 mg, although those who reached 20 mg did not suffer any dose-limiting toxicities [ 22].
Similar(59)
I hope those protests do not escalate.
But it did not escalate any further.
"He should be trying to de-escalate problems, not escalate them.
Do not escalate confrontations.
Do not escalate a fight.
Who's to say things couldn't have escalated this time?
The dose was not escalated, but could be reduced to 250 mg m−2 in the event of significant treatment-emergent toxicity.
In the club's last days, Mr. Reed told patrons he could not afford the escalating rent.
On Thursday, Mr. Christie, a Republican, withdrew state support for the project — known as Access to the Region's Core, or ARC — saying that it would cost New Jersey at least $2.5 billion more than expected and that the state could not afford the escalating total.
To the editor: I disagree strongly with the letter writer who stated that Proposition 13 was designed to help seniors who, before 1978, could not afford the escalating property tax bills.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com