Indeed using global fitting, binding curves could not be fitted properly with the different models included in the BIAevalution 3.0 software (1∶1 Langmuir binding, bivalent analyte, heterogeneous ligand, heterogeneous analyte, conformational change), with or without mass transport.
This nebula, called the Crab Nebula, was so different from other astronomical objects that it could not be fitted into the accepted system of astronomy.
The glass transition temperature of the caramelized matrices could not be fitted with the Gordon Taylor equation, based on the used compounds.
In a penetrometer resistance model that excluded overburden pressure, or depth empirically, penetrometer resistance in deeper layers (>35 cm) could not be fitted accurately.
The killing in places like Lebanon was about local grievances, both ancient and modern, and could not be fitted neatly into a cold-war template.
Difference electron density too large for a water molecule was observed in the putative active site of the enzyme (Supplementary Fig. 7a), which could not be fitted using known buffer components or compounds of the crystallization conditions.
The total scattering could not be fitted using the structure factor for an assembly of hard spheres; a structure factor originally developed for coulombically stabilised micelles was used and excellent fits to the data obtained.
The influence of the substituent (-COOCH2CH3) in ethyl-5-fluoronicotinic acid is even stronger and the T HP time for 19F of 3,5-bis trifluoromethyl pyridine was too short and could not be fitted (see Fig. 4).
In contrast, the yeast telomerase RNA could not be fitted to any known structural model, and the limited number of known sequences from Saccharomyces species did not permit the prediction of a yeast specific conserved structure.
The observed negative temperature coefficient resistance could not be fitted to an usual activation (exponential) law.
A zero inflated negative binomial model could not be fitted to our data since no convergence could be achieved.
