This would not be a disaster, but it could have substantial opportunity costs.
Lee and Robinson will become unrestricted free agents next summer, when about a dozen teams could have substantial cap space.
The financial policy committee's powers to supplement capital requirements are wide-ranging and could have substantial unintended consequences.
Still, stem cells made by nuclear transfer could have substantial advantages over existing stem cell lines for studying basic processes of human development.
Prof. Mark V. Pauly, a health economist at the University of Pennsylvania, said, "Little tax credits don't help very much," But, he added, larger credits could have substantial effects.
Perhaps even more important are changes in the magnitude and frequency of rainfall, which, in combination with a reduced amount of snow and ice, could have substantial impact on the availability of water.
The administration's special envoy for the Middle East, George J. Mitchell, said in a briefing that "the steps announced by the prime minister are significant and could have substantial impact on the ground".
The two sides were said to be exchanging proposals and counterproposals late Tuesday in a showdown that could have substantial ramifications for national security policy and the political climate heading toward Election Day.
The Obama administration's special envoy for the Middle East, George J. Mitchell, called the settlement housing halt "positive" and said "the steps announced by the prime minister are significant and could have substantial impact on the ground".
Yet a new report from the National Academy of Sciences makes a persuasive case that the battle against teenage drinking could have substantial impact if it engaged all elements of society, from the federal government, with its taxing powers, to parents, who may be unaware that their children are drinking.
Chris Matthews, the company's head of sustainability, says Carbon Trust funding was important for Gravitox in that it established the project's credibility not just as a way of saving energy and cutting back on carbon emissions but also as a relatively cheap technology that could have substantial commercial benefits.
