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Matthew Springer, who studies cardiovascular medicine at the University of California, San Francisco (UCSF), wondered whether this difference in where the bone marrow came from could explain divergent results in the research studies: the mice did well, but the human studies were mixed.
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This could explain the divergent usages seen for Gly and Phe, as well as the unusual pattern of usage for Ser.
Yet, intrinsic differences among tests for measuring cellular immune function could explain these divergent results.
This could explain the divergent N-terminal sequence of Dsl1p which is involved in the interaction of the two proteins.
Species-specific differences in the response of fetal growth to maternal hypercholesterolemia could explain the divergent results in animals and humans.
Multiple differences in methods could explain these divergent outcomes for mucin outcomes in periostin deficient mice, including differences in allergen (Aspergillus antigen vs. ovalubumin), mouse strain (mixed vs. C56BL/6) and methods of quantification (semi-quantitative vs. stereology-based).
Recent genomic comparison between three virulent and attenuated B. bovis strain pairs indicate that there are no consistent changes among the protein-coding genes shared between strain pairs that could explain the divergent phenotypes.
While time, temperature for the deep-frying, and a number of other variables were similar in both studies, differences that could explain the divergent results include: initial carotenoid levels in the maize, genotype, and time period the maize was lime-cooked prior to soaking.
If cross-data between tumor topography and patients' countries of origin could be retrieved, it might also help explain divergent HER2-positive GC rates in Latin America.
It is unclear what mechanisms may explain divergent findings between developing countries and the US.
These results lead to the following questions: (1) What are the differences between the 'toxic' and 'nontoxic' types of Hb that could explain such a divergent biologic response?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com