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Sabarth et al. found priming with Vero cell-derived whole virus A/Indonesia/05/2005 based on wild-type strains, followed with A/Vietnam/1194/2004 boosting, could elicit robust immunity against A/Vietnam/1194/2004 in mice model [ 23].
However, in current HA-based UIV research, few of the reported vaccines could elicit robust protective immune responses in animals against lethal viruses challenge or provide cross-protection against different influenza virus strains.
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To test whether Aβ42 protein vaccine or Aβ42 protein plus Aβ42-coding DNA vaccine (coimmunization according to the regimen described in the Methods section) could elicit a robust anti-Aβ42 immune response, C57BL/6 mice were immunized intramuscularly at biweekly intervals.
We found that, in this population, anti-PC IgM levels were associated with a polyunsaturated fatty acid (FA) dihomo-gama-linolic acid 20 3 n-6, and we hypothesized that exposure to easily oxidized FA (for example, in the gut immune system) could elicit more robust anti-PC IgM and IgA levels in contrast to saturated FAs, which are not oxidized.
We demonstrate the ability of this strategy to elicit robust immune responses.
An effective hepatitis C virus (HCV) vaccine should elicit robust humoral and cell mediated immunity (CMI).
DNA vaccines have been shown to elicit robust immune responses in various animal species, from mice to nonhuman primates [1] [11].
Where patient utilities are required, standard methods are available to elicit robust numerical estimates [ 47].
TrxR inhibitors block reduced oxidized thioredoxin to elicit robust S-nitrosylation protein.
We also expected pictorial HWLs to elicit robust activity in the insula.
It is thus clear in the bilayer assay that PIP2 or Gβγ alone are insufficient to elicit robust channel activation.
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