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In addition, data suggest that the accumulation of drug resistance mutations can reduce the replication capacity of HIV-1 [20], which could concomitantly lead to reduced virulence.
Therefore, other factors that could concomitantly explain both arterial and venous thromboses are more likely.
We suggest that these two mechanisms could concomitantly act in breast cancer to prevent the establishment of an effective antitumour immune response.
Taken together, ceftriaxone as a GLT1 upregulator/activator could concomitantly prevent lipid peroxidation and oxidative stress-mediated apoptosis and activate the antioxidant defense system with restoring the levels of GSH.
The colocalisation of CD147 with CD44v3-10, MCT1, MCT1 and MCT4 in this study further suggests that CD147 and CD44v3-10 concomitantlytantly regulate MDR1, MCT1 and MCT4 expression during CaP progression, associated with drug resistance.
Mechanistic investigations revealed that STYK1 could concomitantly activate both the MAPK and PI3K pathways, indicating that it may be standing out as a distinct member of the RPTK family [ 8].
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This model provides a mechanism by which cleavage-type crack growth could proceed concomitantly with significant plastic dissipation.
To understand whether it is loss of, or the imbalance between, fusion and fission that underlies observed cardiac phenotypes, we engineered mice in which Mfn-mediated fusion and Drp1-mediated fission could be concomitantly abolished.
This reduction in concentration of nonchromatin proteins could, therefore, concomitantly with other chromatin modifications, be involved in the shutdown of DNA metabolism in mitosis.
In any case, the two processes, plaque induction of neuritic changes and a contribution of dystrophic neurites to Aβ deposition are not mutually exclusive and could occur concomitantly.
However, there is growing evidence that loss of the normal functions of wild-type huntingtin could act concomitantly and synergistically with the gain of new toxic functions.
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