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Applying this method to the ChIP-seq data of 12 TFs in mouse embryonic stem (ES) cells, we found that the strength of TF-DNA binding could be significantly modulated by cooperative interactions among TFs with adjacent binding sites.
We also speculate that the strength of TF-DNA binding-dissociation could be significantly modulated by cooperative interactions among TFs and DNA-binding signals.
Indeed it is quite possible that when tested at the population level, the neurons that are non-significant at the single neuron level could be significantly modulated when observing an action.
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The inhibitory effects of the CK1e mutants were found at the level of Dvl because the activation of TopFlash by constitutively active (S33A -β-catenin could not be S33A -β-cateninodulated by the overexpreS33A -β-catenin1e.
The results showed the intermediate PS microstructure can be significantly modulated by the etching current density.
A number of transcripts were identified to be significantly modulated for transcriptional factors.
FS neurons however appear to be significantly modulated by trills alone.
But we also show that retinotopic maps may be significantly modulated by eye position gain fields.
Unfortunately, we could not quantify all the glycolytic intermediates, but we could establish that neither glucose-6-phosphate nor fructose-6-phosphate were significantly modulated during apoptosis, suggesting that the caspase-dependent regulation of glycolysis occurred after PFK.
Four host cellular genes were significantly modulated by vaccine ILTV infection, and could represent important secreting regulators to protect cells from cytotoxic damages.
Of the seven cytokines included, we could indeed verify that the serum protein level of both CXCL9 and CXCL10 were significantly modulated in COPD patients, irrespective of their FFMI, compared to healthy controls (Additional file 10).
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