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PKM2 differs from PFK1 in that its activity could be negatively regulated in response to growth factor signaling by binding to tyrosine-phosphorylated proteins [10].
Since V3FL is predominantly detected in liver zones characterized by low Wnt/β−catenin activity levels (Figure 7, A C), it would be tempting to speculate that the expression of V3C18 could be negatively regulated by Wnt/β−catenin signaling.
These results suggest that transcripts of some abiotic stress-responsive genes could be negatively regulated by binding of the APUM5 protein in their 3′ UTR regions.
The activation of plasminogen into plasmin could be negatively regulated by the physiological inhibitors, namely plasminogen activator inhibitor (PAI -1 and -2 [ 24].
Expression of alkaline phosphatase (ALP) and in vitro mineralization are suggestive of osteogenic functions and these could be negatively regulated when osteoblasts are challenged with microbial stimuli.
Four putative inhibitory pathways acting on HDAC are illustrated in Fig. 4. (1) Experiments in C2C12 cells suggest that HDAC5 could be negatively regulated by AMPK by activating salt inducible kinase (SIK1) (Takemori et al., 2008).
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This phosphatase could be constitutively active if the rate of Gwl phosphorylation by CDK1 during M phase is higher than the rate of Gwl dephosphorylation, or this enzyme could conceivably be negatively regulated directly or indirectly by CDK1.
Sprouting angiogenesis can also be negatively regulated.
In the second model, SesAp may negatively regulate SesBp but also be negatively regulated by SesBp.
Furthermore, Yap can be negatively regulated by Akt [ 29, 30].
Decapping can also be negatively regulated on specific mRNAs.
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