In vitro drug release study indicated that PECT/DOX Ms were sustainedly shed from the native PECT/DOX MHg formulation, which could be internalized by tumor cells with rapid intracellular DOX release.
Based on the observations that both Vti1b and VAMP7 can be transported as part of a cis-SNARE complex (Miller et al., 2007; Pryor et al., 2008), one possibility was that VAMPs 8, 3, and 2 could be internalized as a complex with their acceptor (Q-) SNAREs (a syntaxin and a SNAP) (Gordon et al., 2009).
Therefore, most plasma proteases which are entrapped in a complex with alpha-2 macroglobulin could be internalized into the yolk together with the antiprotease.
More researches were focused on biological effects of fullerene, graphene, and carbon nanotubes (CNTs) modified with various bioactive groups on multiple type cells [17 38]; they revealed that carbon nanoparticles could be internalized in cells and react with subcellular organelles, such as endosome, mitochondria, lysosome, and nucleus [24 28, 30].
The CLSM analysis revealed that the proposed FA-RMCNCs with core-shell constructure could be internalized selectively by the HeLa cells through the folate-mediated endocytosis.
It is found that the cubic particles with a size of 3 um could be internalized by HeLa cells, although it was only limited.
In vitro cellular uptakes of such nanoparticles were investigated with CLSM, demonstrating the coumarin 6-loaded PCL-PLA-TPGS nanoparticles could be internalized by Hela cells.
We found that C. albicans could be internalized into mast cells, which seemed to occur rarely.
After systemic administration in mice, TH-Lip could be internalized into tumor cells efficaciously.
