Costs were derived from Medicare 2010 reimbursement rates.
Intervention costs were derived from information collected during the trial.
Intervention-related costs were derived using information collected during the trial, administrative records, and published unit costs.
Data on incidences, effectiveness and costs were derived from scientific literature and publicly available databases.
All other costs were derived through self-estimates, which could be a threat to internal validity.
All costs were derived from the accounting system of our hospital.
Drug costs were derived from ex-factory prices, adjusted with 7.5% mandatory rebate.
Health care consumption and reimbursed costs were derived from a database of a Dutch health insurance company.
Acceptance of testing, return rates, and related costs were derived from a randomized trial of 251 patients; long-term costs and health outcomes were derived from the literature.
Inpatient costs were derived from official G-DRGs codes (German Diagnosis Related Groups) in 2010 which are calculated based on resource use in 2008 (see Table 5).
Data on the cost-effectiveness of drugs and the direct and indirect costs were derived from a clinical study by Savi et al. [15].
