Sentence examples for costly alignment from inspiring English sources

The transitive alignment (via first neighbour) between the query structure and second neighbour is used as starting point for refinement, skipping the costly alignment optimization from scratch.

By applying a Needleman Wunsch (Needleman and Wunsch, 1970) modified to allow a DAG along one axis we obtain the least costly alignment of the candidate and the corresponding path.

In other words, we perform the costly network alignment algorithm only for the networks that fall into the third case.

Thus, conserved structure search methods make use of readily available data sets: RNAz makes use of conserved structure databases covering only a small portion of the genome [10], MSARI needs alignments of conserved sequences from as much as 10 different species [8] and EvoFold needs a costly genome-wide alignment of several genome sequences [9].

When used with costly biological network alignment tools, the time complexity of these indexing methods become impractical.

This alignment is costly for long reads but has a clear optimization function, as read errors are corrected by the best voting correction in the MSA.

For example, the generation of new alignments for each sequence is both computational costly, and does not take advantage of available curated alignments that make use of ss-RNA secondary structure to guide the primary sequence alignment.

Covariation algorithms use a number of simplifying heuristics (reviewed in [ 50]), as simultaneous folding and alignment of RNA sequences is computationally costly [ 51].

Since much of the alignment must be done manually, manufacturing is costly and time-consuming, says Mario Dagenais, professor of electrical and computer engineering at the University of Maryland.

Alignment of two networks is a very costly operation, which makes exhaustive comparison of all the database networks with a query impractical.

This allows optimal alignment of interface specificity sites, without producing energetically costly conformational changes, essential for high-affinity binding.